PRED MILD (prednisolone acetate ophthalmic suspension, USP) 0.12% is a topical anti-inflammatory agent for ophthalmic use.
PRED MILD is indicated for the treatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).
Pharmacological classification PRED MILD
Ophthalmic preparations with corticosteroids.
PHARMACOLOGICAL ACTION PRED MILD
Prednisolone acetate steroids. Glucocorticoids inhibit the edema, fibrin deposition, capillary expansion and phagocytic migration of the acute inflammatory response, as well as capillary proliferation, collagen deposition and scar formation.
INDICATIONS PRED MILD
Mild to moderate non-infectious allergic and inflammatory diseases of the lid, conjunctiva, cornea and sclera (including chemical and thermal burns).
CONTRAINDICATIONS PRED MILD
Acute, untreated purulent ocular infections, superficial herpes simplex (dendritic keratitis), the vaccine, chickenpox and other viral diseases of the cornea and conjunctiva, ocular tuberculosis and fungal diseases of the eye, and sensitivity to the drug.
WARNINGS
As the possibility of adverse effects on the corneal permeability and the danger of destruction of the corneal epithelium with prolonged or repeated use of benzalkonium chloride preserved preparations can not be excluded, regular ophthalmological examination is required.
Caution should be exercised in the use of benzalkonium chloride preserved topical medication over an extended period in patients with extensive ocular surface disease.
DOSAGE AND DIRECTIONS FOR USE PRED MILD
From 1 to 2 drops instilled into the conjunctival sac two to four times a day. During the initial 24 to 48 hours, the dose can be safely increased to 2 drops every hour. Care should be taken not to discontinue therapy prematurely. Shake the container well before using.
Side effects and special PRED MILD
Posterior subcapsular cataract formation was reported after heavy or prolonged use of topical ophthalmic corticosteroids. Patients with a history of herpes simplex should be treated with caution. In those diseases causing thinning of the cornea, perforation has been reported with the use of topical steroids. Since PRED MILD does not contain an antibacterial agent, if infection is present, appropriate measures should be taken to counteract the body involved. Acute purulent eye infection may be masked or expand through the use of topical steroids. Use of steroid drugs in the presence of stromal herpes simplex requires caution and should be accompanied by frequent mandatory slit-lamp microscopy. As fungal infections of the cornea reported coincidentally with long-term local steroid applications, fungal invasion may be suspected in any persistent corneal ulceration where steroid use or used. The use of topical corticosterioids may cause increased intraocular pressure in some people. This can cause damage to the optic nerve with defects in visual fields. It is advisable that intraocular pressure be checked frequently. Because of the potential cause of corneal abscess, fungal keratopathy glaucoma patient should be referred to an ophthalmologist if the eye does not respond within 48 hours.
Use during pregnancy:
Safety of intensive or prolonged use of topical steroids during pregnancy has not been substantiated.
Known symptoms of overdosage and especially its treatment of
See “Side effects and special Precautions’listed above.
